RFC 21005 – Chloroprene
Chloroprene RFC Letter (pdf) Toxicological Review of Chloroprene (CAS No. 126-99-8) In Support of Summary Information on the Integrated Risk Information System (IRIS)
EPA Response to RFC 21005 Chloroprene (pdf) EPA Response to RFC 21005 dated 3/14/2022
Exhibit A: Incorporation of In Vitro Metabolism Data in a Physiologically Based Pharmacokinetic (PBPK) Model for Chloroprene- Revised Documentation in Response to USEPA Peer Review (pdf) Report by Ramboll dated July 15, 2021.
Attachments to Exhibit A:
- Supplemental Materials A: Supplemental Tables Supplemental Materials A: Supplemental Tables (pdf)
- Supplemental Materials B: Re-estimation of Metabolism Supplemental Materials B: Re-estimation of Metabolism Parameters (pdf)
- Supplemental Materials C: IVIVE Literature Supplemental Materials C: IVIVE Literature Review (pdf)
- Supplemental Materials D: Metabolism Parameter Calculations Supplemental Materials D: Metabolism Parameter Calculations (xlsx)
- Supplemental Materials E: Model Files Supplemental Materials E: Model Files (pdf)
- Supplemental Materials F: Reactive Metabolite Modeling Supplemental Materials F: Reactive Metabolite Modeling (pdf)
- Supplemental Materials G: Responses to Peer Reviewer Comments Supplemental Materials G: Responses to Peer Reviewer (pdf)
Exhibit B: Epidemiological Basis for Supporting a Correction of the Chloroprene Inhalation Unit Risk (IUR) (pdf) Report by Ramboll dated July 15, 2021